Schistosoma haematobium total antigen induces increased proliferation, migration and invasion, and decreases apoptosis of normal epithelial cells

• Type: Article in International Scientific Journal
• Date: 2010

Authors

Botelho, MC (Author) Other; Machado JC (Author) FMUP; da Costa, JMC (Author) Other

Journal

Title: Virulence

Vol. 1

Pages: 84-87

ISSN: 2150-5594

Publisher: Taylor & Francis

Indexing

ISI Web of Knowledge - 24 Citations

Scopus - 28 Citations

Other information

Authenticus ID: P-003-921

DOI: 10.4161/viru.1.2.10487

Abstract (EN): Schistosoma haematobium is a parasitic flatworm that infects millions of people, mostly in the developing world, and is associated with high incidence of bladder cancer although why is not clear. But our group was able to define the mechanistic relationship for the first time between infection of S. haematobium and cancer. We used in vitro models to demonstrate the presence of informative carcinogenesis-associated phenotypes in CHO cells exposed to Sh total antigen, in which we showed increased cell proliferation, decreased apoptosis, upregulation of the anti-apoptotic molecule Bcl-2, downregulation of the tumor suppressor protein p27, and increased cell migration and invasion. We further discuss the molecular and cellular events that might be responsible for schistosomiasis-related bladder cancer. © 2010 Landes Bioscience.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 4