Variable distribution of TFF2 (spasmolysin) alleles in Europeans does not indicate predisposition to gastric cancer

• Type: Article in International Scientific Journal
• Date: 1999

Authors

Silva, ED (Author) Other; Kayademir, T (Author) Other; Regateiro, F (Author) Other; Machado JC (Author) Other; Savas, S (Author) Other; Dobosz, T (Author) Other; Blin, N (Author) Other; Gott, P (Author) Other

Journal

Title: Human Heredity

Vol. 49

Pages: 45-47

ISSN: 0001-5652

Publisher: Karger

Indexing

ISI Web of Knowledge - 4 Citations

Scopus - 7 Citations

Other information

Authenticus ID: P-001-5QN

DOI: 10.1159/000022839

Abstract (EN): Peptides belonging to the trefoil factor family (TFF) protect the gastrointestinal epithelia, Overexpression of TFFs was observed in pathological conditions such as gastritis, ulceration, metaplasia and neoplasia of the gastrointestinal tract. The aims of this work were to investigate the recently described TFF2 gene polymorphism in different European populations. DNA samples from blood of healthy individuals and gastric cancer patients were genotyped using the polymerase chain reaction. They were compared to a gastric cancer population. The results do not show any significant difference in allelic frequencies between gastric cancer patients and healthy individuals from Portugal. However, the frequency of the two alleles found varies considerably among Europeans.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 3