Gastric Cancer: Basic Aspects

• Type: Article in International Scientific Journal
• Date: 2011

Authors

Resende, C (Author) Other; Thiel, A (Author) Other; Machado JC (Author) FMUP; Ristimaki, A (Author) Other

Journal

Title: Helicobacter

Vol. 16

Pages: 38-44

ISSN: 1083-4389

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge - 54 Citations

Scopus - 58 Citations

Other information

Authenticus ID: P-002-N0Z

DOI: 10.1111/j.1523-5378.2011.00879.x

Abstract (EN): Gastric cancer (GC) is a world health burden, ranging as the second cause of cancer death worldwide. Etiologically, GC arises not only from the combined effects of environmental factors and susceptible genetic variants but also from the accumulation of genetic and epigenetic alterations. In the last years, molecular oncobiology studies brought to light a number of genes that are implicated in gastric carcinogenesis. This review is intended to focus on the recently described basic aspects that play key roles in the process of gastric carcinogenesis. Genetic variants of the genes IL-10, IL-17, MUC1, MUC6, DNMT3B, SMAD4, and SERPINE1 have been reported to modify the risk of developing GC. Several genes have been newly associated with gastric carcinogenesis, both through oncogenic activation (GSK3 beta, CD133, DSC2, P-Cadherin, CDH17, CD168, CD44, metalloproteinases MMP7 and MMP11, and a subset of miRNAs) and through tumor suppressor gene inactivation mechanisms (TFF1, PDX1, BCL2L10, XRCC, psiTPTE-HERV, HAI-2, GRIK2, and RUNX3). It also addressed the role of the inflammatory mediator cyclooxygenase-2 (COX-2) in the process of gastric carcinogenesis and its importance as a potential molecular target for therapy.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 7