Go to:
Logótipo
Comuta visibilidade da coluna esquerda
Você está em: Start > Publications > View > Nerve Growth Factor in Bladder Dysfunction: Contributing Factor, Biomarker, and Therapeutic Target
Publication

Publications

Nerve Growth Factor in Bladder Dysfunction: Contributing Factor, Biomarker, and Therapeutic Target

Title
Nerve Growth Factor in Bladder Dysfunction: Contributing Factor, Biomarker, and Therapeutic Target
Type
Article in International Scientific Journal
Year
2011
Authors
Ochodnicky, P
(Author)
Other
The person does not belong to the institution. The person does not belong to the institution. The person does not belong to the institution. Without AUTHENTICUS Without ORCID
Cruz C.D.
(Author)
FMUP
View Personal Page You do not have permissions to view the institutional email. Search for Participant Publications View Authenticus page View ORCID page
Yoshimura, N
(Author)
Other
The person does not belong to the institution. The person does not belong to the institution. The person does not belong to the institution. Without AUTHENTICUS Without ORCID
Michel, MC
(Author)
Other
The person does not belong to the institution. The person does not belong to the institution. The person does not belong to the institution. Without AUTHENTICUS Without ORCID
Journal
Vol. 30
Pages: 1227-1241
ISSN: 0733-2467
Publisher: Wiley-Blackwell
Other information
Authenticus ID: P-002-Z7M
Abstract (EN): In the last two decades, nerve growth factor (NGF), initially described as a prototypical trophic factor in the development of sensory and sympathetic innervation, has emerged as a complex regulator of neural plasticity along the micturition pathways. This review aims to summarize the current experimental and clinical evidence for a role of NGF in urinary bladder. Experimental administration of NGF elicits the states of increased sensation, urgency, and bladder hyperreflexia, resembling pathologies associated with bladder overactivity and inflammatory pain, such as overactive bladder syndrome (OAB) and interstitial cystitis/painful bladder syndrome (IC/PBS). There is strong experimental evidence, including the effective therapeutic targeting, on the direct causal role of NGF in rodent models of bladder outlet obstruction, spinal cord injury, diabetic bladder dysfunction, and interstitial inflammation. In humans, there are attempts to employ urinary NGF levels as a diagnostic marker in various forms of OAB and IC/PBS. In near future, use of novel experimental tools, such as urothelium-specific NGF transgenic mice or more specific low-molecular weight NGF receptor modulators, may provide better understanding of several unresolved issues in NGF-related bladder dysfunction. Moreover, successful experimental therapeutic approaches, such as NGF sequestering proteins or modified NGF antibodies, await the translation to the clinical treatment of bladder disorders. Neurourol. Urodynam. 30:1227-1241, 2011. (C) 2011 Wiley-Liss, Inc.
Language: English
Type (Professor's evaluation): Scientific
No. of pages: 15
Documents
We could not find any documents associated to the publication.
Related Publications

Of the same journal

The urinary and prostatic microbiome in non-neurogenic male LUTS/BPH: A systematic review (2024)
Another Publication in an International Scientific Journal
Pina-Vaz, T; Silva, AC; Silva, C; Miranda, I; Francisco Cruz; Silva, JA
Neurotrophins in Bladder Function: What Do We Know and Where Do We Go From Here? (2014)
Another Publication in an International Scientific Journal
Cruz C.D.
Is the Urothelium Intelligent? (2010)
Another Publication in an International Scientific Journal
Birder, LA; Kanai, AJ; Francisco Cruz; Moore, K; Fry, CH
Is it Possible to Regenerate the Underactive Detrusor? Part 2 Electrical Stimulation Therapies, Treatment of Bladder Outlet Obstruction, Constipation, and Pelvic Floor Disorders ICI-RS 2024 (2024)
Another Publication in an International Scientific Journal
Sinha, S; Gajewski, JB; Tarcan, T; Van Huele, A; Francisco Cruz; Martinez, EM; Przydacz, M; Kheir, GB; Lombardo, R; Wein, A; Abrams, P

See all (26)

Recommend this page Top
Copyright 1996-2025 © Faculdade de Direito da Universidade do Porto  I Terms and Conditions  I Acessibility  I Index A-Z
Page created on: 2025-07-10 at 04:17:44 | Privacy Policy | Personal Data Protection Policy | Whistleblowing