Formas farmacêuticas de libertação modificada

• Type: Article in International Scientific Journal
• Date: 1999

Authors

Paulo Costa (Author) FFUP; Sousa Lobo JM (Author) FFUP

Journal

Title: Revista Portuguesa de Farmacia

Vol. 49 No. 4

Pages: 181-190

ISSN: 0484-811X

Publisher: Ordem dos Farmaceuticos

Indexing

Scopus - 11 Citations

Other information

Authenticus ID: P-007-2F1

Abstract (EN): The development of pharmaceutical forms in which the drug release is, in same way, influenced by the surrounding physical-chemical system is leading to a higher interest in the study of the occurring mechanisms during that process. While dissolution rate is a drug characteristic, the release rate is the result of the complete pharmaceutical system containing that drug. Accordingly with the proposed biopharmaceutical classification system the drugs can be classified into four basic groups, according to their solubility properties and their ability to penetrate the gastrointestinal mucosa, into high or low solubility class and high or low permeability class. An immediate release dosage form can be categorised as belonging to a rapid or slow dissolving class. The systematisation of the most commonly used type of pharmaceutical systems and release mechanisms is referred. The processes occurring in the majority of the modified release systems can be included in one of three categories: A) drug diffusion, B) activation processes and C) matrix swelling and dissolution/erosion at the matrix periphery. In order to resolve some release problems some new specials pharmaceutical systems are been proposed.

Language: Portuguese

Type (Professor's evaluation): Scientific