Alterations in glycosylation as biomarkers for cancer detection

• Type: Another Publication in an International Scientific Journal
• Date: 2010

Authors

Celso Reis (Author) ICBAS; Osorio, H (Author) Other; Silva, L (Author) Other; Gomes, C (Author) Other; David L (Author) FMUP

Journal

Title: JOURNAL OF CLINICAL PATHOLOGY

Vol. 63

Pages: 322-329

ISSN: 0021-9746

Indexing

ISI Web of Knowledge - 316 Citations

Scopus - 326 Citations

Other information

Authenticus ID: P-003-7WJ

DOI: 10.1136/jcp.2009.071035

Abstract (EN): Glycoconjugates constitute a major class of biomolecules which include glycoproteins, glycosphingolipids and proteoglycans. Glycans are involved in several physiological and pathological conditions, such as host-epathogen interactions, cell differentiation, migration, tumour invasion and metastisation, cell trafficking and signalling. Cancer is associated with glycosylation alterations in glycoproteins and glycolipids. This review describes various aspects of protein glycosylation with the focus on alterations associated with human cancer. The application of these glycosylation modifications as biomarkers for cancer detection in tumour tissues and serological assays is summarised.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 8