Setting reference values for exhaled nitric oxide: a systematic review

• Type: Another Publication in an International Scientific Journal
• Date: 2013

Authors

Jacinto T (Author) FMUP; Alving, K (Author) Other; Ricardo Cruz Correia (Author) FMUP; Costa-Pereira A (Author) FMUP; Fonseca, J (Author) FMUP

Journal

Title: Clinical Respiratory Journal

Vol. 7 No. 2

Pages: 113-120

ISSN: 1752-6981

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge - 23 Citations

Scopus - 28 Citations

Other information

Authenticus ID: P-005-1W9

DOI: 10.1111/j.1752-699x.2012.00309.x

Abstract (EN): Background The values obtained when the fraction of exhaled nitric oxide (FeNO) is measured are affected by several factors that are specific to the individual patient, making interpretation difficult, especially in the initial assessment of patients with respiratory symptoms. Methods Systematic review of studies on FeNO reference values and individual-specific factors that influence them. Results From 3739 references, 15 studies were included. Four studies included children and adolescents. In nine studies, samples were selected from the general population. Most studies reported objective measures for atopy (nine studies), but not for smoking status (one). Significant determinants of FeNO values reported were age and height (seven studies), atopy (six), smoking (four), weight (four), sex (three) and race (three). Additional factors were included in eight studies. R2 was reported in only five studies. The logarithmic transformation of FeNO was inadequately described in seven studies. Conclusion There are several equations for FeNO reference values that may be used in clinical practice, although the factors they include and the statistical methods they use vary considerably. We recommend the development of standard methods for the evaluation of normal FeNO data and that reference equations should be formulated based on a predetermined physiological model.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 8