Methodologies for the detection of adverse drug reactions: comparison of hospital databases, chart review and spontaneous reporting

• Type: Another Publication in an International Scientific Journal
• Date: 2013

Authors

Miguel, A (Author) Other; Azevedo L (Author) FMUP; Lopes, F (Author) Other; Freitas A (Author) FMUP; Costa-Pereira A (Author) FMUP

Journal

Title: Pharmacoepidemiology and Drug Safety

Vol. 22 No. 1

Pages: 98-102

ISSN: 1053-8569

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge - 33 Citations

Scopus - 33 Citations

Other information

Authenticus ID: P-002-1HW

DOI: 10.1002/pds.3348

Abstract (EN): Purpose To evaluate a methodology for adverse drug reactions (ADRs) detection through hospital databases. Methods A retrospective analysis was conducted to identify ADRs using diagnostic codes from databases, later validated by chart review. An independent chart review was performed for comparison, as well as assessment of spontaneous reports. Results 325 ADRs were identified (prevalence of 2.41%, positive predictive value of 87.6%). Independent chart review identified 9% of ADRs at a cost of 35 person-hours (versus two person-hours in databases). There were seven spontaneous reports of ADRs. Conclusions Although not frequently used, the detection of ADRs through databases is a relatively less expensive, fast and effective methodology that can improve current pharmacovigilance systems. Copyright (C) 2012 John Wiley & Sons, Ltd.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 5