Ulcerative Colitis in Northern Portugal and Galicia in Spain

• Type: Article in International Scientific Journal
• Date: 2010

Authors

Barreiro De Acosta, M (Author) Other; Magro F (Author) FMUP; Carpio, D (Author) Other; Lago, P (Author) Other; Echarri, A (Author) Other; Cotter, J (Author) Other; Pereira, S (Author) Other; Goncalves, R (Author) Other; Lorenzo, A (Author) Other; Carvalho, L (Author) Other; Castro, J (Author) Other; Barros, L (Author) Other; Dias, JA (Author) Other; Rodrigues, S (Author) Other; Portela, F (Author) Other; Dias C (Author) FMUP; Costa-Pereira A (Author) FMUP; Alvarez, MV (Author) Other; Carpintero, P (Author) Other; Dancausa, L (Author) Other; De Castro, ML (Author) Other; Villaverde, AF (Author) Other; Hernandez, V (Author) Other; Ares, DM (Author) Other; Cadilla, JM (Author) Other; Ollero, V (Author) Other; Prada, JIR (Author) Other; Santos, E (Author) Other; Dourado, RV (Author) Other; Vega, P (Author) Other; Nunes, ACR (Author) Other; Valente, AI (Author) Other; Vieira, AI (Author) Other; Duarte, A (Author) Other; Marques, A (Author) Other; Queiroz, A (Author) Other; Ribeiro, B (Author) Other; Duesca, C (Author) Other; Viveiros, CF (Author) Other; Caetano, C (Author) Other; Sequeira, C (Author) Other; Horta, D (Author) Other; Gencsi, E (Author) Other; Monteiro, E (Author) Other; Silva, FG (Author) Other; Marinho, G (Author) Other; Cardoso, H (Author) Other; Vasconcelos, H (Author) Other; Sousa, H (Author) Other; Morna, H (Author) Other; Lopes, H (Author) Other; Bastos, I (Author) Other; Medeiros, I (Author) Other; Seves, I (Author) Other; Rosa, I (Author) Other; Baranda, J (Author) Other; De Deus, JR (Author) Other; Lopes, JG (Author) Other; Freitas, J (Author) Other; De Matos, JP (Author) Other; Reis, J (Author) Other; Vieira, J (Author) Other; Estevens, J (Author) Other; Ribeiro, JM (Author) Other; Matos, L (Author) Other; Correia, L (Author) Other; Jasmins, L (Author) Other; Lebre, L (Author) Other; Gloria, L (Author) Other; Tavares, L (Author) Other; Cravo, M (Author) Other; Marques, M (Author) Other; Cremers, MI (Author) Other; Maldonado, MDR (Author) Other; Correia, M (Author) Other; De Lurdes Goncalves, M (Author) Other; Cesar, M (Author) Other; Areia, M (Author) Other; Ferreira, M (Author) Other; Campos, MJ (Author) Other; Salgado, M (Author) Other; Almeida, N (Author) Other; Andrade, P (Author) Other; Ministro, P (Author) Other; Santos, PM (Author) Other; Peixe, P (Author) Other; Caldeira, P (Author) Other; Freire, P (Author) Other; Martins, P (Author) Other; Ferreira, R (Author) Other; Freire, R (Author) Other; Loureiro, R (Author) Other; Sousa, R (Author) Other; Cerqueira, R (Author) Other; Sousa, S (Author) Other; Lima, SC (Author) Other; Alberto, SF (Author) Other; Leite, S (Author) Other; Mendes, S (Author) Other; Barroso, S (Author) Other; Lopes, S (Author) Other; Nobre, S (Author) Other; Bana E Costa, T (Author) Other; Fernandes, V (Author) Other

Journal

Title: Inflammatory Bowel Diseases

Vol. 16

Pages: 1227-1238

ISSN: 1078-0998

Publisher: Oxford University Press

Indexing

ISI Web of Knowledge - 10 Citations

Scopus - 13 Citations

Other information

Authenticus ID: P-003-597

DOI: 10.1002/ibd.21170

Abstract (EN): Background: Clinical and therapeutic patterns of ulcerative colitis (UC) are variable in different world regions. The purpose of this study was to examine two close independent southern European UC populations from 2 bordering countries and observe how demographic and clinical characteristics of patients can influence the severity of UC. Methods: A cross-sectional study was conducted during a 15-month period (September 2005 to December 2006) based on data of 2 Web registries of UC patients. Patients were stratified according to the Montreal Classification and disease severity was defined by the type of treatment taken. Results: A total of 1549 UC patients were included, 1008 (65%) from northern Portugal and 541 (35%) from Galicia (northwest Spain). A female predominance (57%) was observed in Portuguese patients (P < 0.001). The median age at diagnosis was 35 years and median years of disease was 7. The majority of patients (53%) were treated only with mesalamine, while 15% had taken immunosuppressant drugs, and 3% biologic treatment. Most patients in both groups were not at risk for aggressive therapy. Extensive colitis was a predictive risk factor for immunosuppression in northern Portugal and Galicia (odds ratio [OR] 2.737, 95% confidence interval [Cl]: 1.846-4.058; OR 5.799, 95% Cl: 3.433-9.795, respectively) and biologic treatment in Galicia (OR 6.329, 95% CI: 2.641-15.166). Younger patients presented a severe course at onset with more frequent use of immunosuppressors in both countries. Conclusions: In a large population of UC patients from two independent southern European countries, most patients did not require aggressive therapy, but extensive colitis was a clear risk factor for more severe disease.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 12