Epithelial E- and P-cadherins: Role and clinical significance in cancer

• Type: Another Publication in an International Scientific Journal
• Date: 2012

Authors

Joana Paredes (Author) FMUP; Figueiredo, J (Author) Other; Albergaria, A (Author) FMUP; Oliveira, P (Author) Other; Carvalho, J (Author) Other; Ribeiro, AS (Author) Other; Caldeira, J (Author) Other; Costa, AM (Author) Other; Simoes Correia, J (Author) Other; Oliveira, MJ (Author) FCUP; Pinheiro, H (Author) Other; Pinho, SS (Author) Other; Mateus, R (Author) Other; Celso Reis (Author) ICBAS; Marina Leite (Author) Other; Fernandes, MS (Author) Other; Fernando Schmitt (Author) FMUP; Carneiro F (Author) FMUP; Figueiredo C (Author) FMUP; Oliveira, C (Author) Other; Seruca, R (Author) FMUP

Journal

Title: Biochimica et Biophysica Acta - Reviews on Cancer

Vol. 1826

Pages: 297-311

ISSN: 0304-419X

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 169 Citations

Scopus - 183 Citations

Other information

Authenticus ID: P-002-34Z

DOI: 10.1016/j.bbcan.2012.05.002

Abstract (EN): E-cadherin and P-cadherin are major contributors to cell-cell adhesion in epithelial tissues, playing pivotal roles in important morphogenetic and differentiation processes during development, and in maintaining integrity and homeostasis in adult tissues. It is now generally accepted that alterations in these two molecules are observed during tumour progression of most carcinomas. Genetic or epigenetic alterations in E- and P-cadherin-encoding genes (CDH1 and CDH3, respectively), or alterations in their proteins expression, often result in tissue disorder, cellular de-differentiation, increased invasiveness of tumour cells and ultimately in metastasis. In this review, we will discuss the major properties of E- and P-cadherin molecules, its regulation in normal tissue, and their alterations and role in cancer, with a specific focus on gastric and breast cancer models.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 15