BAX and BCL-2 polymorphisms, as predictors of proliferative vitreoretinopathy development in patients suffering retinal detachment: the Retina 4 project

• Type: Article in International Scientific Journal
• Date: 2015

Authors

Pastor Idoate, S (Author) Other; Rodriguez Hernandez, I (Author) Other; Rojas, J (Author) Other; Fernandez, I (Author) Other; Garcia Gutierrez, MT (Author) Other; Ruiz Moreno, JM (Author) Other; Rocha-Sousa A (Author) FMUP; Ramkissoon, YD (Author) Other; Harsum, S (Author) Other; MacLaren, RE (Author) Other; Charteris, DG (Author) Other; Van Meurs, JC (Author) Other; Gonzalez Sarmiento, R (Author) Other; Pastor, JC (Author) Other

Journal

Title: Acta Ophthalmologica

Vol. 93

Pages: E541-E549

ISSN: 1755-375X

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge - 13 Citations

Scopus - 13 Citations

Other information

Authenticus ID: P-00G-MRJ

DOI: 10.1111/aos.12718

Abstract (EN): PurposeTo compare the distribution of BCL-2 -938C>A (rs2279115) and BAX -248G>A (rs4645878) genotypes among European subjects undergoing rhegmatogenous retinal detachment (RRD) surgery in relation to the further development of proliferative vitreoretinopathy (PVR). MethodsA case-control gene association study, as a part of Retina 4 project, was designed. rs2279115 and rs4645878 polymorphisms were analysed in 555 samples from patients with RRD (134 with PVR secondary to surgery). Proportions of genotypes and AA homozygous groups of BCL-2 and BAX polymorphisms between subsamples were analysed in two phases. Genotypic and allelic frequencies were compared in global sample and in subsamples. ResultsBAX: Differences were observed in the genotype frequencies and in AA carriers between controls and cases in the global series. The odds ratio (OR) of A carriers in the global sample was 1.7 (95% CI: 1.23-2.51). Proportions of genotypes in Spain+Portugal were significant different. The OR of A carriers from Spain and Portugal was 1.8 (95% CI: 1.11-2.95). BCL-2: No significant differences were observed in genotype frequencies. However, proportions of genotypes in Spain+Portugal were significant. A protective effect (OR: 0.6 95% CI: 0.43-0.96) was found in A carriers from Spain and Portugal. ConclusionsResults suggest that A allele of rs4645878 could be a biomarker of high risk of developing PVR in patients undergoing RD surgery. The possible role of BCL-2 (inhibitor of necroptosis pathway) as a possible new target in PVR prophylaxis should be investigated.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 9