POSSIBLE ROLE FOR FUNDUS AUTOFLUORESCENCE AS A PREDICTIVE FACTOR FOR VISUAL ACUITY RECOVERY AFTER EPIRETINAL MEMBRANE SURGERY

• Type: Article in International Scientific Journal
• Date: 2014

Authors

Brito, PN (Author) Other; Gomes, NL (Author) Other; Vieira, MP (Author) Other; Faria, PA (Author) Other; Fernandes, AV (Author) Other; Rocha-Sousa A (Author) FMUP; Falcão-Reis F (Author) FMUP

Journal

Title: Retina

Vol. 34

Pages: 273-280

ISSN: 0275-004X

Publisher: Wolters Kluwer Health

Indexing

ISI Web of Knowledge - 20 Citations

Scopus - 25 Citations

Other information

Authenticus ID: P-009-75M

DOI: 10.1097/iae.0b013e3182999a02

Abstract (EN): Purpose: To study the potential association between fundus autofluorescence, spectral-domain optical coherence tomography, and visual acuity in patients undergoing surgery because of epiretinal membranes. Methods: Prospective, interventional case series including 26 patients submitted to vitrectomy because of symptomatic epiretinal membranes. Preoperative evaluation consisted of a complete ophthalmologic examination, autofluorescence, and spectral-domain optical coherence tomography. Studied variables included foveal autofluorescence (fov. AF), photoreceptor inner segment/outer segment (IS/OS) junction line integrity, external limiting membrane integrity, central foveal thickness, and foveal morphology. All examinations were repeated at the first, third, and sixth postoperative months. The main outcome measures were logarithm of minimal angle resolution visual acuity, fov. AF integrity, and IS/OS integrity. Results: All cases showing a continuous IS/OS line had an intact fov. AF, whereas patients with IS/OS disruption could have either an increased area of foveal hypoauto-fluorescence or an intact fov. AF, with the latter being associated with IS/OS integrity recovery in follow-up spectral-domain optical coherence tomography imaging. The only preoperative variables presenting a significant correlation with final visual acuity were baseline visual acuity (P = 0.047) and fov. AF grade (P = 0.023). Conclusion: Recovery of IS/OS line integrity after surgery, in patients with preoperative IS/OS disruption and normal fov. AF, can be explained by the presence of a functional retinal pigment epithelium-photoreceptor complex, supporting normal photoreceptor activity. Autofluorescence imaging provides a functional component to the study of epiretinal membranes, complementing the structural information obtained with optical coherence tomography.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 8