Clinicopathological Significance of Immunoexpression of Claudin-1 and Claudin-7 in Feline Mammary Carcinomas

• Type: Article in International Scientific Journal
• Date: 2014

Authors

Dias Pereira P (Author) ICBAS; Flores AR (Author) Other; Rema A (Author) ICBAS; Carvalho F (Author) ICBAS; lopes, g (Author) ICBAS; Augusto Faustino (Author) ICBAS

Journal

Title: Journal of Comparative Pathology

Vol. 151

Pages: 339-346

ISSN: 0021-9975

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 1 Citation

Scopus - 3 Citations

Other information

Authenticus ID: P-00A-5QQ

DOI: 10.1016/j.jcpa.2014.07.006

Abstract (EN): Claudins (CLDNs) are tight junction proteins that have a role in regulating cell adhesion and polarity, paracellular permeability, proliferation and differentiation. Several immunohistochemical studies have shown reduced expression of CLDN-1 and CLDN-7 in human and canine mammary carcinomas, suggesting that these proteins may participate in mammary carcinogenesis, invasion and metastasis. The present study characterizes expression of CLDN-1 and CLDN-7 in feline mammary carcinomas (n = 52) and their metastases (n = 29). There was an inverse association between CLDN-7 expression and histological grade of tumour. Reduced expression of CLDN-7 was significantly associated with decreased tubule formation, high proliferative activity and metastasis. No significant associations were found between CLDN-1 expression and any of these features. Evaluation of expression of CLDN-7, but not CLDN-1, may therefore provide prognostic information, assisting in the diagnosis of a subgroup of aggressive feline mammary carcinomas that share some features with the recently described 'claudin-low' subgroup of human breast cancer.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 8