Psychological follow-up of presymptomatic genetic testing for spinocerebellar ataxia type 2 (SCA2) in Cuba

• Type: Article in International Scientific Journal
• Date: 2007

Authors

Paneque, M (Author) Other; Carolina Lemos (Author) Other; Escalona, K (Author) Other; Prieto, L (Author) Other; Reynaldo, R (Author) Other; Velazquez, M (Author) Other; Quevedo, J (Author) Other; Santos, N (Author) Other; Almaguer, LE (Author) Other; Velazquez, L (Author) Other; Alda Sousa (Author) ICBAS; Fleming, M (Author) Other; Sequeiros, J (Author) ICBAS

Journal

Title: Journal of Genetic Counseling

Vol. 16

Pages: 469-479

ISSN: 1059-7700

Publisher: Springer Nature

Indexing

Scopus - 14 Citations

Other information

Authenticus ID: P-007-JBB

DOI: 10.1007/s10897-006-9083-y

Abstract (EN): Presymptomatic testing for spinocerebellar ataxia type 2 (SCA2) in Cuba started five years ago. We have now investigated the psychological impact of test results on 150 individuals at 50% risk for SCA2. In a prospective study, psychological instruments were used to evaluate depression, anxiety and family functioning (1) before testing and (2) one year after disclosure of the test result. One year after, anxiety and depression levels decreased both in carriers and non-carriers, but anxiety decreased significantly more in carriers. Pathological levels of anxiety were seen mostly in members of dysfunctional families, but decreased more in them than in other consultands. Presymptomatic testing thus seems to have been especially beneficial for these testees, possibly due to a greater gain from the psychosocial support received. It would be pertinent to evaluate now the impact of other psychosocial variables and perform longer-term longitudinal studies. © 2007 Springer Science+Business Media, LLC.

Language: English

Type (Professor's evaluation): Scientific