The C677T polymorphism in MTHFR is not associated with migraine in Portugal

• Type: Article in International Scientific Journal
• Date: 2008

Authors

Ferro, A (Author) Other; Castro, MJ (Author) Other; Carolina Lemos (Author) Other; Santos, M (Author) Other; Alda Sousa (Author) ICBAS; Pereira Monteiro, J (Author) Other; Sequeiros, J (Author) ICBAS; Maciel, P (Author) Other

Journal

Title: Disease Markers

Vol. 25

Pages: 107-113

ISSN: 0278-0240

Publisher: Hindawi

Indexing

ISI Web of Knowledge - 12 Citations

Scopus - 13 Citations

Other information

Authenticus ID: P-004-31W

DOI: 10.1155/2008/178679

Abstract (EN): Migraine is a debilitating disorder affecting a large proportion of the population. The effect of methylenetrathydrofolate reductase (GeneID: 4524) polymorphisms in migraine etiology and development has been a theme of great interest. Several populations were evaluated with contradictory results. In this case-control study, we investigated the effect of the C677T polymorphism in MTHFR, as a genetic risk factor for migraine, in the Portuguese population. We observed that, overall, there was no significant difference in the frequencies of MTHFR C677T genotypes or of the T-allele among the Portuguese migraineurs when compared to controls. There was also no association of migraine with aura with MTHFR genotypes or with the T-allele, in contrast with previous studies. Regarding the risk of the T-allele homozygote carriers, there was an equal probability to develop migraine with aura over migraine without aura in our patients. Thus, we conclude that the C677T MTHFR polymorphism, responsible for a reduction of the MTHFR activity in folate metabolism, is not a major genetic susceptibility factor for migraine in the Portuguese population.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 7