Immunohistochemical analysis of urokinase plasminogen activator and its prognostic value in canine mammary tumours

• Type: Article in International Scientific Journal
• Date: 2011

Authors

Santos, A (Author) Other; Lopes, C (Author) Other; Marques, RM (Author) Other; Amorim, I (Author) Other; Ribeiro, J (Author) Other; Frias, C (Author) Other; Corália Vicente (Author) ICBAS; Gaertner, F (Author) Other; Augusto Matos (Author) ICBAS

Journal

Title: Veterinary Journal

Vol. 189

Pages: 43-48

ISSN: 1090-0233

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 12 Citations

Scopus - 13 Citations

Other information

Authenticus ID: P-002-Q0T

DOI: 10.1016/j.tvjl.2010.05.023

Abstract (EN): Urokinase plasminogen activator (uPA) has been associated with aggressive behaviour and poor prognosis in human breast cancer, but there is no information on its expression in canine mammary tumours (CMT). uPA immunohistochemical expression was studied in 119 CMT (24 benign, 95 malignant) to investigate its relationship with clinical and histopathological parameters. Dogs with malignant mammary tumours (MMT) underwent a 2-year follow-up evaluation. MMT expressed significantly more uPA than benign tumours. In MMT, high uPA stromal expression was significantly associated with larger tumour size, high Ki-67 expression, invasive growth, high histological grade, regional lymph node metastases, development of distant metastases, and lower overall survival (OS) and disease-free survival (DFS). On the basis of these results, uPA could be considered a useful prognostic factor in dogs with MMT.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 6