Immunohistochemical Expression of Vascular Endothelial Growth Factor in Canine Mammary Tumours

• Type: Article in International Scientific Journal
• Date: 2010

Authors

Santos, AAF (Author) Other; Oliveira, JT (Author) Other; Lopes, CCC (Author) Other; Amorim, IF (Author) Other; Corália Vicente (Author) ICBAS; Gaertner, FRM (Author) Other; Augusto Matos (Author) ICBAS

Journal

Title: Journal of Comparative Pathology

Vol. 143

Pages: 268-275

ISSN: 0021-9975

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 18 Citations

Scopus - 14 Citations

Other information

Authenticus ID: P-003-1G0

DOI: 10.1016/j.jcpa.2010.04.006

Abstract (EN): The histopathological and clinical aspects of canine mammary tumours (CMTs) have been widely studied, but the variation in the biological behaviour of these neoplasms hampers the identification of prognostic factors. Sustained angiogenesis has been suggested to be one of the most important factors underlying tumour growth and invasion. This process involves the action of several growth factors including vascular endothelial growth factor (VEGF). The present study characterizes the relationship between immunohistochemical expression of VEGF and gross (e.g. size and tissue fixation) and microscopical (e.g. type, growth, necrosis, lymphoid infiltration, lymph node metastasis, histological grade and proliferation index) features of CMTs. Forty-eight benign and 64 malignant CMTs were evaluated. Statistical analysis failed to show a significant relationship between VEGF expression and the pathological features, suggesting that VEGF expression occurs in both benign and malignant tumours and is independent of histological type, proliferation, tissue invasion or local metastatic capacity.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 8