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Sgt1, a co-chaperone of Hsp90 stabilizes Polo and is required for centrosome organization

Title
Sgt1, a co-chaperone of Hsp90 stabilizes Polo and is required for centrosome organization
Type
Article in International Scientific Journal
Year
2009
Authors
Martins, T
(Author)
Other
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Maia, AF
(Author)
Other
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Steffensen, S
(Author)
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Sunkel, CE
(Author)
ICBAS
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Journal
Title: EMBO JournalImported from Authenticus Search for Journal Publications
Vol. 28
Pages: 234-247
ISSN: 0261-4189
Publisher: Wiley-Blackwell
Other information
Authenticus ID: P-003-N7X
Abstract (EN): Sgt1 was described previously in yeast and humans to be a Hsp90 co-chaperone and required for kinetochore assembly. We have identified a mutant allele of Sgt1 in Drosophila and characterized its function. Mutations in sgt1 do not affect overall kinetochore assembly or spindle assembly checkpoint. sgt1 mutant cells enter less frequently into mitosis and arrest in a prometaphase-like state. Mutations in sgt1 severely compromise the organization and function of the mitotic apparatus. In these cells, centrioles replicate but centrosomes fail to mature, and pericentriolar material components do not localize normally resulting in highly abnormal spindles. Interestingly, a similar phenotype was described previously in Hsp90 mutant cells and correlated with a decrease in Polo protein levels. In sgt1 mutant neuroblasts, we also observe a decrease in overall levels of Polo. Overexpression of the kinase results in a substantial rescue of the centrosome defects; most cells form normal bipolar spindles and progress through mitosis normally. Taken together, these findings suggest that Sgt1 is involved in the stabilization of Polo allowing normal centrosome maturation, entry and progression though mitosis.
Language: English
Type (Professor's evaluation): Scientific
No. of pages: 14
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