Microtubule-associated proteins and their essential roles during mitosis

• Type: Another Publication in an International Scientific Journal
• Date: 2004

Authors

Helder Maiato (Author) Other; Sampaio, P (Author) Other; Sunkel, CE (Author) ICBAS

Journal

The Journal is awaiting validation by the Administrative Services.

Title: INTERNATIONAL REVIEW OF CYTOLOGY - A SURVEY OF CELL BIOLOGY, VOL 241

Vol. 157

Pages: 53-+

ISSN: 0074-7696

Publisher: Academic Press - Elsevier

Indexing

ISI Web of Knowledge - 60 Citations

Scopus - 62 Citations

Other information

Authenticus ID: P-000-D08

DOI: 10.1016/s0074-7696(04)41002-x

Abstract (EN): Microtubules play essential roles during mitosis, including chromosome capture, congression, and segregation. In addition, microtubules are also required for successful cytokinesis. At the heart of these processes is the ability of microtubules to do work, a property that derives from their intrinsic dynamic behavior. However, if microtubule dynamics were not properly regulated, it is certain that microtubules alone could not accomplish any of these tasks. In vivo, the regulation of microtubule dynamics is the responsibility of microtubule-associated proteins. Among these, we can distinguish several classes according to their function: (1) promotion and stabilization of microtubule polymerization, (2) destabilization or severance of microtubules, (3) functioning as linkers between various structures, or (4) motility-related functions. Here we discuss how the various properties of microtubule-associated proteins can be used to assemble an efficient mitotic apparatus capable of ensuring the bona fide transmission of the genetic information in animal cells.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 103