The spindle assembly checkpoint: Preventing chromosome mis-segregation during mitosis and meiosis

• Type: Another Publication in an International Scientific Journal
• Date: 2006

Authors

Malmanche, N (Author) Other; Maia, A (Author) Other; Sunkel, CE (Author) ICBAS

Journal

Title: FEBS Letters

Vol. 580

Pages: 2888-2895

ISSN: 0014-5793

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge - 55 Citations

Scopus - 65 Citations

Other information

Authenticus ID: P-004-KQS

DOI: 10.1016/j.febslet.2006.03.081

Abstract (EN): Aneuploidy is a common feature of many cancers, suggesting that genomic stability is essential to prevent tumorigenesis. Also, during meiosis, chromosome non-disjunction produces gamete imbalance and when fertilized result in developmental arrest or severe birth defects. The spindle assembly checkpoint prevents chromosome mis-segregation during both mitosis and meiosis. In mitosis, this control system monitors kinetochore-microtubule attachment while in meiosis its role is still unclear. Interestingly, recent data suggest that defects in the spindle assembly checkpoint are unlikely to cause cancer development but might facilitate tumour progression. However, in meiosis a weakened checkpoint could contribute to age-related aneuploidy found in humans.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 8