IMMUNOHISTOCHEMICAL ANALYSIS OF RAS ONCOGENE-P21 PRODUCT IN HUMAN GASTRIC CARCINOMAS AND THEIR ADJACENT MUCOSAS

• Type: Article in International Scientific Journal
• Date: 1992

Authors

Carneiro F (Author) FMUP; David L (Author) FMUP; Sunkel, CE (Author) ICBAS; LOPES, C (Author) Other; Sobrinho Simoes, M (Author) FMUP

Journal

Title: Pathology Research and Practice

Vol. 188

Pages: 263-272

ISSN: 0344-0338

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 10 Citations

Scopus - 11 Citations

Other information

Authenticus ID: P-001-PQP

Abstract (EN): In an attempt to clarify the relationship between ras oncogene expression and the clinico-pathological features of malignant and pre-malignant lesions of the stomach we undertook the immunohistochemical study of the expression of ras gene p21 product in a series of eighty gastric carcinomas and their respective adjacent mucosas. In two cases the mRNA of Ha-ras was also studied by in situ hybridization. The majority of gastric carcinomas as well as their adjacent non-neoplastic mucosas expressed ras gene product. There was a significant relationship between the expression of ras gene p21 product and the morphologic pattern of the tumours. An enhanced ras expression was found in several conditions regarded as precursor lesions of intestinal and/or diffuse types of gastric carcinoma (dysplasia, foveolar hyperplasia and even the neck zone of normal-appearing gastric glands, namely in the mucosa adjacent to diffuse carcinomas). Ras expression was actually more prominent in most of these conditions than in their respective adjacent carcinomas. No significant relationship was found between ras expression and invasiveness of the wall, nodal metastases and venous invasion.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 10