Go to:
Logótipo
Comuta visibilidade da coluna esquerda
Você está em: Start > Publications > View > Developmental changes in calcium dynamics, Protein Kinase C distribution and Endoplasmic Reticulum organization in human preimplantation embryos
Publication

Publications

Developmental changes in calcium dynamics, Protein Kinase C distribution and Endoplasmic Reticulum organization in human preimplantation embryos

Title
Developmental changes in calcium dynamics, Protein Kinase C distribution and Endoplasmic Reticulum organization in human preimplantation embryos
Type
Article in International Scientific Journal
Year
1996
Authors
barros, a
(Author)
FMUP
View Personal Page You do not have permissions to view the institutional email. Search for Participant Publications View Authenticus page View ORCID page
Tesarik, J
(Author)
Other
The person does not belong to the institution. The person does not belong to the institution. The person does not belong to the institution. Without AUTHENTICUS Without ORCID
Journal
Vol. 2
Pages: 967-977
ISSN: 1360-9947
Indexing
Other information
Authenticus ID: P-007-74B
Abstract (EN): Developmental changes in the Ca2+ dynamics of human zygotes and preimplantation embryos were related to changes in the distribution of endoplasmic reticulum (ER) and protein kinase C (PKC). The fertilization-induced Ca2+ oscillations were typically observed over >5 h, were ryanodine-sensitive and showed a periphery-to-centre propagation of Ca2+ waves. At the same time, ER and PKC were accumulated in the cell periphery. After the appearance of pronuclei, ryanodine-sensitive Ca2+ oscillations of lower amplitude and frequency were observed until the pronuclear breakdown. However, Ca2+ waves then began in the perinuclear region, in the area of ER and PKC accumulation and spread towards the cell periphery. During the second to fourth cell cycle, small sinusoidal Ca2+ fluctuations were observed; sparse higher-amplitude Ca2+ spikes, superimposed on these basal fluctuations, appeared shortly before cell division. The sinusoidal Ca2+ fluctuations were asynchronous in individual blastomeres and disappeared progressively in arrested embryos. The direction of Ca2+ wave propagation and the distribution of ER and PKC were similar to the situation observed in pronuclear zygotes. In contrast to the zygotes, ryanodine did not arrest the Ca2+ oscillations but augmented their amplitude and frequency. These data suggest that human pre-embryos use different mechanisms of Ca2+ signalling in the early post-fertilization period, during the pronuclear development and during cleavage. © European Society for Human Reproduction and Embryology.
Language: English
Type (Professor's evaluation): Scientific
Documents
We could not find any documents associated to the publication.
Related Publications

Of the same authors

Role of Ca2+ oscillations during human preimplantation embryo development (1997)
Another Publication in an International Scientific Journal
sousa, m; barros, a; Mendoza, C; Tesarik, J
Current problems with spermatid conception (1998)
Another Publication in an International Scientific Journal
sousa, m; barros, a; Tesarik, J
Intracytoplasmic injection of ejaculate and testicle spermatids: report on 35 cycles (1998)
Other Publications
barros, a; Bernabeu, R; Takahashi, K; Oliveira, C; Cremades, N; Silva, J; sousa, m; Tesarik, J
The role of ryanodine-sensitive Ca2+ stores in the Ca2+ oscillation machine of human oocytes (1996)
Article in International Scientific Journal
sousa, m; barros, a; Tesarik, J

See all (12)

Of the same journal

Regucalcin, a calcium-binding protein with a role in male reproduction? (2012)
Another Publication in an International Scientific Journal
Laurentino, SS; Correia, S; cavaco, je; Oliveira, PF; sousa, m; barros, a; Socorro, S
Xanthohumol impairs glucose uptake by a human first-trimester extravillous trophoblast cell line (HTR-8/SVneo cells) and impacts the process of placentation (2015)
Article in International Scientific Journal
Ana Correia Branco; Claudia F Azevedo; Joao R Araujo; Joao T Guimaraes; Ana Faria; Elisa Keating; Fatima Martel
The role of ryanodine-sensitive Ca2+ stores in the Ca2+ oscillation machine of human oocytes (1996)
Article in International Scientific Journal
sousa, m; barros, a; Tesarik, J
Superoxide dismutase expression in human cumulus oophorus cells (2009)
Article in International Scientific Journal
Matos, L; Stevenson, D; Gomes, F; Silva Carvalho, JL; Almeida, H
Sperm parameters and epididymis function in transgenic rats overexpressing the Ca-2-binding protein regucalcin: a hidden role for Ca-2 in sperm maturation? (2013)
Article in International Scientific Journal
correia, s; oliveira, pf; guerreiro, pm; lopes, g; alves, mg; canario, avm; cavaco, je; socorro, s

See all (16)

Recommend this page Top
Copyright 1996-2025 © Faculdade de Direito da Universidade do Porto  I Terms and Conditions  I Acessibility  I Index A-Z
Page created on: 2025-07-10 at 00:28:38 | Privacy Policy | Personal Data Protection Policy | Whistleblowing