Overall survival in women with breast cancer: The influence of Pepsinogen C gene polymorphism

• Type: Article in International Scientific Journal
• Date: 2008

Authors

Pinto Correia, AL (Author) Other; Pinto, D (Author) Other; Pereira, D (Author) Other; Rodrigues, H (Author) Other; de Sousa, JA (Author) Other; Sousa, H (Author) Other; Sousa, B (Author) Other; Sousa, S (Author) Other; Lopes, C (Author) ICBAS; Rui Medeiros (Author) ICBAS

Journal

Title: DNA and Cell Biology

Vol. 27

Pages: 333-336

ISSN: 1044-5498

Publisher: Mary Ann Liebert

Indexing

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Other information

Authenticus ID: P-003-YQ9

DOI: 10.1089/dna.2007.0713

Abstract (EN): We aimed to study the role of an insertion/deletion polymorphism in the Pepsinogen C (PGC) gene in the clinical outcome of 172 breast cancer patients. The six polymorphic alleles were amplified using PCR. Our results indicate that patients carrying the allele 6 present a higher 5-year survival mean (83.4% of 6 allele carriers were alive at 5 years vs. only 68.6% of noncarriers, p = 0.001), suggesting a role for this polymorphism in the outcome of breast cancer patients. We hypothesize that PGC polymorphism can be a predictive biomarker in breast cancer, contributing to an individual profile of great interest in clinical oncology.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 4