Dietary unsaturated fatty acids differently affect catecholamine handling by adrenal chromaffin cells

• Type: Article in International Scientific Journal
• Date: 2015

Authors

Gomes, A (Author) Other; Correia, G (Author) Other; Coelho, M (Author) Other; Araújo JR (Author) FMUP; Pinho, MJ (Author) Other; Teixeira, AL (Author) Other; Rui Medeiros (Author) ICBAS; ribeiro, l (Author) FMUP

Journal

Title: Journal of Nutritional Biochemistry

Vol. 26

Pages: 563-570

ISSN: 0955-2863

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 8 Citations

Scopus - 9 Citations

Other information

Authenticus ID: P-00A-CH5

DOI: 10.1016/j.jnutbio.2014.12.009

Abstract (EN): Catecholamines (CA) play an important role in cardiovascular (CDV) disease risk. Namely, noradrenaline (NA) levels positively correlate whereas adrenaline (AD) levels negatively correlate with obesity and/or CDV disease. Western diets, which are tipically rich in Omega-6 fatty acids (FAs) and deficient in Omega-3 FAs, may contribute to the development of obesity, type 2 diabetes and/or coronary artery disease. Taking this into consideration and the fact that our group has already described that saturated FAs affect catecholamine handling by adrenal chromaffin cells, this work aimed to investigate the effect of unsaturated FAs upon catecholamine handling in the same model. Our results showed that chronic exposure to unsaturated FAs differently modulated CA cellular content and release, regardless of both FA series and number of carbon atoms. Namely, the Omega-6 arachidonic and linoleic acids, based on their effect on CA release and cellular content, seemed to impair NA and AD vesicular transport, whereas gamma-linolenic acid selectively impaired AD synthesis and release. Within the Omega-9 FAs, oleic acid was devoid of effect, and elaidic acid behaved similarly to gamma-linolenic acid. Eicosapentaenoic and docosahexaenoic acids (Omega-3 series) impaired the synthesis and release of both NA and AD. These results deserve attention and future development, namely, in what concerns the mechanisms involved and correlative effects in vivo.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 8