Expression of E-cadherin, P-cadherin and beta-catenin in canine malignant mammary tumours in relation to clinicopathological parameters, proliferation and survival

• Type: Article in International Scientific Journal
• Date: 2008

Authors

Gama, A (Author) Other; Joana Paredes (Author) FMUP; Fátima Gärtner (Author) ICBAS; Alves, A (Author) Other; Fernando Schmitt (Author) FMUP

Journal

Title: Veterinary Journal

Vol. 177

Pages: 45-53

ISSN: 1090-0233

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 58 Citations

Scopus - 66 Citations

Other information

Authenticus ID: P-003-YDY

DOI: 10.1016/j.tvjl.2007.05.024

Abstract (EN): Cadherin-catenin complexes play a critical role in intercellular adhesion, and their altered expression has been implicated in tumour progression. In this study, the expression of E-cadherin, P-cadherin and beta-catenin was analysed in 65 canine malignant mammary tumours and correlated with clinicopathological parameters, proliferation and survival. Reduction in E-cadherin expression was significantly associated with increased tumour size, high histological and invasion grades, lymph node metastasis and high mitotic index. Reduced beta-catenin expression was associated with high histological and invasion grades. Anomalous expression of P-cadherin was only associated with invasion. In 39 cases for which follow-up data were available, reduced E-cadherin and beta-catenin expression was significantly associated with shorter overall survival and disease free survival. Abnormal expression of adhesion molecules is a common phenomenon in canine mammary malignant tumours and may play a central role in tumour progression.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 9