E-cadherin expression in canine malignant mammary tumours: Relationship to other clinico-pathological variables

• Type: Article in International Scientific Journal
• Date: 2006

Authors

Augusto Matos (Author) ICBAS; Lopes, C (Author) ICBAS; carvalheira, j (Author) ICBAS; Santos, M (Author) Other; Rutteman, GR (Author) Other; Fátima Gärtner (Author) ICBAS

Journal

Title: Journal of Comparative Pathology

Vol. 134

Pages: 182-189

ISSN: 0021-9975

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 38 Citations

Scopus - 55 Citations

Other information

Authenticus ID: P-004-NFS

DOI: 10.1016/j.jcpa.2005.10.004

Abstract (EN): The relationship between E-cadherin epithelial expression, as detected by immunohistochemical methods, and other clinico-pathological characteristics of canine malignant mammary tumours was studied in 77 tumours surgically removed from 45 female dogs. The immunohistochemical assessment was based on the estimated percentage of epithelial cells with membranous labelling. Reduction Of E-cadherin expression was significantly related to size and ulceration of tumours but not to fixation to skin or underlying tissue; it was also related to lymph node metastasis, necrosis and infiltrative growth. Histological type (but not histological grade) was related to E-cadherin expression, with solid tumours more frequently lacking expression and tubulopapillary tumours showing increased expression as compared with the Other types. The significant relationship between E-cadherin and other known factors of poor prognosis suggests that the loss of E-cadherin expression may have prognostic value in canine malignant mammary tumours.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 8