Immunohistochemical study of hormonal receptors and cell proliferation in normal canine mammary glands and spontaneous mammary tumours

• Type: Article in International Scientific Journal
• Date: 2000

Authors

Geraldes, M (Author) Other; Fátima Gärtner (Author) ICBAS; Fernando Schmitt (Author) FMUP

Journal

Title: Veterinary Record

Vol. 146

Pages: 403-406

ISSN: 0042-4900

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge - 55 Citations

Scopus - 67 Citations

Other information

Authenticus ID: P-001-0GS

Abstract (EN): The expression of hormone receptors and their relationship-to cell proliferation in six samples of normal canine mammary tissue, and 11 benign and 10 malignant mammary neoplasms from female dogs were assessed by immunohistochemistry in formalin-fixed paraffin-embedded samples, by using monoclonal antibodies against progesterone and oestrogen receptors, and nuclear antigen Ki-67 (MIB-1). Malignant tumours negative for progesterone receptors proliferated at higher rates than progesterone receptor-positive tumours, suggesting that the progression towards malignancy in spontaneous mammary tumours is accompanied by a decrease in hormonal steroid dependency. Only one malignant tumour was positive for oestrogen receptors.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 4