MIB-1 labelling indices according to clinico-pathological variables in canine mammary tumours: A multivariate study

• Type: Article in International Scientific Journal
• Date: 2006

Authors

Augusto Matos (Author) ICBAS; Célia Lopes (Author) ICBAS; Faustino, AM (Author) Other; carvalheira, j (Author) ICBAS; dos Santos, MSA (Author) Other; Rutteman, GR (Author) Other; Fátima Gärtner (Author) ICBAS

Journal

Title: Anticancer Research

Vol. 26

Pages: 1821-1826

ISSN: 0250-7005

Publisher: International Institute of Anticancer Research

Indexing

ISI Web of Knowledge - 10 Citations

Scopus - 17 Citations

Other information

Authenticus ID: P-004-KTV

Abstract (EN): The relationship between MIB-1 labelling indices (LI), as detected by immunohistochemical methods, and other clinico-pathological characteristics was studied in a series of 77 malignant mammary tumours surgically removed from 4 7 female dogs. The immunostaining was assessed on the basis of the estimated percentage of positive cells in the areas of highest labelling. Multivariate logistic regression demonstrated no influence of breed, age, previous pregnancies, previous progestin administration, histological type or location of the tumour on MIB-1 L1. MIB-1 LI was significantly related to the size of the tumour, necrosis, invasive growth and histological grade, but not with ulceration, lymph node metastasis, skin fixation or E-cadherin expression. The significant relationship between MIX-1 LI and other known factors of poor prognosis suggests that a high LI may have prognostic value in canine malignant mammary tumours.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 6