Unraveling the role of the Target of Rapamycin signaling in sphingolipid metabolism

• Type: Another Publication in an International Scientific Journal
• Date: 2016

Authors

Vítor Teixeira (Author) ICBAS; Vitor Costa (Author) ICBAS

Journal

Title: Progress in Lipid Research

Vol. 61

Pages: 109-133

ISSN: 0163-7827

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 13 Citations

Scopus - 20 Citations

Scientific classification

FOS: Natural sciences > Biological sciences

Other information

Authenticus ID: P-00K-2G8

DOI: 10.1016/j.plipres.2015.11.001

Abstract (EN): Sphingolipids are important bioactive molecules that regulate basic aspects of cellular metabolism and physiology, including cell growth, adhesion, migration, senescence, apoptosis, endocytosis, and autophagy in yeast and higher eukaryotes. Since they have the ability to modulate the activation of several proteins and signaling pathways, variations in the relative levels of different sphingolipid species result in important changes in overall cellular functions and fate. Sphingolipid metabolism and their route of synthesis are highly conserved from yeast to mammalian cells. Studies using the budding yeast Saccharomyces cerevisiae have served in many ways to foster our understanding of sphingolipid dynamics and their role in the regulation of cellular processes. In the past decade, studies in S. cerevisiae have unraveled a functional association between the Target of Rapamycin (TOR) pathway and sphingolipids, showing that both TOR Complex 1 (TORC1) and TOR Complex 2 (TORC2) branches control temporal and spatial aspects of sphingolipid metabolism in response to physiological and environmental cues. In this review, we report recent findings in this emerging and exciting link between the TOR pathway and sphingolipids and implications in human health and disease.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 25