The yeast model system as a tool towards the understanding of apoptosis regulation by sphingolipids

• Type: Article in International Scientific Journal
• Date: 2013

Authors

António Rego (Author) Other; Dário Trindade (Author) Other; Susana R. Chaves (Author) Other; Stéphen Manon (Author) Other; Vitor Costa (Author) ICBAS; Maria João Sousa (Author) Other; Manuela Côrte-Real (Author) Other

Journal

Title: FEMS Yeast Research

Vol. 14

Pages: 160-178

ISSN: 1567-1356

Publisher: Oxford University Press

Indexing

ISI Web of Knowledge - 20 Citations

Scopus - 31 Citations

Scientific classification

FOS: Natural sciences > Biological sciences

Other information

Authenticus ID: P-00H-V0P

DOI: 10.1111/1567-1364.12096

Abstract (EN): It has been established that sphingolipids are engaged in the regulation of apoptosis both as direct executors and as signalling molecules. However, the peculiarities of this class of bioactive lipids, namely the interconnectivity of their metabolic pathways, the specific subcellular localization where they are generated and the transport mechanisms involved, introduce a considerably high level of complexity in deciphering their role in the signalling and regulation of programmed cell death. Although yeast is undeniably a simple model, the conservation of the sphingolipid metabolism and of the core machinery engaged in regulated cell death has already provided valuable clues to the understanding of metabolic pathways involved in distinct cellular processes, including apoptosis. It can be anticipated that studies using this model system will further unravel mechanisms underlying the regulation of apoptosis by sphingolipids and contribute to novel therapeutic strategies against serious human diseases associated with dysfunction of sphingolipid-dependent cell death programmes.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 19