Dendritic right/left asymmetries in the neurons of the human hippocampal formation - A quantitative Golgi study

• Type: Article in International Scientific Journal
• Date: 2007

Authors

Maria Jose Sa (Author) Other; Carlos Ruela (Author) Other; Maria Dulce Madeira (Author) FMUP

Journal

Title: Arquivos de Neuro-Psiquiatria

Vol. 65

Pages: 1105-1113

ISSN: 0004-282X

Publisher: Associacao Arquivos de Neuro-Psiquiatria Dr. Oswaldo Lange

Indexing

ISI Web of Knowledge - 6 Citations

Scopus - 7 Citations

Scientific classification

FOS: Medical and Health sciences > Basic medicine

Other information

Authenticus ID: P-004-5V4

DOI: 10.1590/s0004-282x2007000700003

Abstract (EN): Objective: To search for right/left asymmetries in the dendritic trees of the neuronal populations and in the cell-free layer volumes of the human hipoccampal formation. Method: In necropsic material obtained from six male individuals we performed a quantitative Golgi study of the dendritic trees of dentate granules, CA3 and CA1 pyramidal neurons and a volumetric analysis of dentate gyrus molecular layer, strata oriens plus alveus and strata lacunosum-moleculare plus radiatum of CA3 and CA1 fields. Results: We found inter-hemispheric asymmetries in the dendrites trees of all neurons, reaching the significant level in the number of granule cells dendritic segments (higher in the left than in the right hemisphere), dendritic branching density of CA3 pyramidal cells and mean dendritic length of CA1 apical terminal segments (higher in the right than in the opposite side). No volumetric differences were observed. Conclusion: This study points to different anatomical patterns of connectivity in the hippocampal formations of both hemispheres which may underlie functional asymmetries.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 9