STRUCTURES OF 2 N(1)-BOUND PLATINUM(II)-6-OXOPURINE COMPLEXES - COMPARISONS WITH COMPLEXES DERIVED FROM PLATINUM(II) ANTI-TUMOR AGENTS

• Type: Article in International Scientific Journal
• Date: 1979

Authors

KISTENMACHER, TJ (Author) Other; WILKOWSKI, K (Author) Other; DECASTRO, B (Author) FEUP; CHIANG, CC (Author) Other; MARZILLI, LG (Author) Other

Journal

Title: Biochemical and Biophysical Research Communications

Vol. 91

Pages: 1521-1527

ISSN: 0006-291X

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 18 Citations

Scopus - 8 Citations

Scientific classification

FOS: Natural sciences > Biological sciences

Other information

Authenticus ID: P-005-6H1

DOI: 10.1016/0006-291x(79)91237-3

Abstract (EN): The preparation and molecular structure of [(diethylenetriamine) (7,9-dimethylhypoxanthine) platinum(II)] (PF6)2·1.5H2O and [(ethylenediamine) (7,9-dimethylhypoxanthine)2platinum(II)] (PF6)2, are reported. These complexes represent the first structurally characterized N(1)-bound Pt(II) 6-oxopurine complexes. In each case, the Pt(II)N(1) bond length [2.051(6)A in the diethylenetriamine complex and 2.021(8)A in the ethylenediamine complex] indicates a strong metal-to-base binding. Both complexes contain interligand hydrogen bonds, with the ammine ligand acting as the donor and the O(6) atom of the base acting as the acceptor. These N(1)-bound complexes are compared with N(7)-bound 6-oxopurine and N(3)-bound cytosine complexes of Pt(II) anti-tumor agents. © 1979.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 7