LONG-TERM ALCOHOL-CONSUMPTION REDUCES THE NUMBER OF NEURONAL NUCLEAR-PORES - A MORPHOMETRIC STUDY UNDERTAKEN IN CA3 HIPPOCAMPAL PYRAMIDS OF RATS

• Type: Article in International Scientific Journal
• Date: 1988

Authors

ANDRADE, JP (Author) FMUP; CADETELEITE, A (Author) Other; PAULABARBOSA, MM (Author) Other; VOLK, B (Author) Other; TAVARES, MA (Author) FMUP

Journal

Title: Alcoholism: Clinical and Experimental Research

Vol. 12

Pages: 286-289

ISSN: 0145-6008

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge - 10 Citations

Scopus - 8 Citations

Scientific classification

FOS: Medical and Health sciences > Health sciences

Other information

Authenticus ID: P-001-TFG

DOI: 10.1111/j.1530-0277.1988.tb00196.x

Abstract (EN): A close relationship between the number of nuclear pores and the cellular protein synthesis activity is known to exist. Previous biochemical investigations lead to admit that the widespread neuronal alcohol-induced degenerative changes could depend on a decrease in the neuronal protein synthesis. The morphometric analysis made on the nuclear pore complexes of CA3 hippocampal pyramids of long-term alohol-fed rats fully supports this attractive hypothesis, since it has been found a marked reduction in the number of pores per unit surface area of nuclear membrane, together with a reduction in their total number per nucleus.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 4