Endoplasmic reticulum stress response in non-alcoholic steatohepatitis: The possible role of physical exercise

• Type: Article in International Scientific Journal
• Date: 2015

Authors

Emanuel Passos (Author) Other; António Alexandre Moreira Ribeiro de Ascensão (Author) FADEUP; Maria Joao Martins (Author) FMUP; J. Magalhães (Author) FADEUP

Journal

Title: Metabolism: Clinical and Experimental

Vol. 64 No. 7

Pages: 780-792

ISSN: 0026-0495

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 23 Citations

Scopus - 24 Citations

Scientific classification

FOS: Medical and Health sciences > Clinical medicine

Other information

Authenticus ID: P-00G-5EH

DOI: 10.1016/j.metabol.2015.02.003

Abstract (EN): Sedentary lifestyle coupled with excessive consumption of high caloric food has been related to the epidemic increase of non-alcoholic fatty liver disease, which can progress from simple steatosis to non-alcoholic steatohepatitis (NASH), fibrosis, cirrhosis and, eventually, may culminate in hepatocellular carcinoma. Although the precise mechanisms underlying the progression of NASH are not completely understood, endoplasmic reticulum (ER) dysfunction seems to play a key role in the process. Hepatic ER stress has been associated to hepatic steatosis, insulin resistance, inflammation, oxidative stress and hepatocyte death, contributing to liver dysfunction. Physical exercise seems to be the most effective preventive and therapeutic non-pharmacological strategy to mitigate several features related to NASH, possibly targeting most of the referred mechanisms associated with the pathophysiology of ER-related NASH. Nevertheless, little is known about the impact of physical exercise on NASH-related ER stress. In this review, we will discuss the ER stress associated to NASH conditions and highlight the possible benefits of physical exercise in the attenuation and/or reversion of NASH-related ER stress.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 13