The protein kinase inhibitor balanol: Structure-activity relationships and structure-based computational studies

• Type: Article in International Scientific Journal
• Date: 2008

Authors

Vineet Pande (Author) Other; Maria J Ramos (Author) FCUP; Federico Gago (Author) Other

Journal

Title: Anti-Cancer Agents in Medicinal Chemistry

Vol. 8

Pages: 638-645

ISSN: 1871-5206

Publisher: Bentham Science

Indexing

ISI Web of Knowledge - 17 Citations

Scopus - 22 Citations

Scientific classification

FOS: Medical and Health sciences > Basic medicine

Other information

Authenticus ID: P-003-X49

Abstract (EN): Balanol, a fungal metabolite, is a potent ATP-competitive inhibitor of Protein Kinase C (PKC) and Protein Kinase A (PKA), important targets in oncology. Since its discovery in 1993, a number of studies have been performed in order to design selective and bioavailable balanol analogs. Several crystal structures of PKA in complex with balanol and a few analogs bound within the catalytic site have also been solved providing insight about the key interactions for binding. The PKA-balanol complex has also served as an interesting model system for structure-based ligand design and validation of a number of computational methodologies aimed at both understanding the physical basis for molecular recognition and addressing the important issue of protein flexibility in ligand binding. We provide an overview of the structure-activity relationships of balanol analogs and summarize the progress made in structural and computational studies involving balanol.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 8