Oncogenic HPV types infection in adolescents and university women from North Portugal: From self-sampling to cancer prevention

• Type: Article in International Scientific Journal
• Date: 2011

Authors

Silva, J (Author) Other; Ribeiro, J (Author) Other; Sousa, H (Author) Other; Cerqueira, F (Author) Other; Teixeira, AL (Author) Other; Baldaque, I (Author) Other; Osorio, T (Author) Other; Medeiros, R (Author) ICBAS

Journal

Title: Journal of Oncology

Vol. 2011

Pages: 1-8

ISSN: 1687-8450

Publisher: Hindawi

Indexing

ISI Web of Knowledge

Scopus - 16 Citations

Other information

Authenticus ID: P-008-1VY

DOI: 10.1155/2011/953469

Abstract (EN): This study aimed to characterize the HPV infection status in adolescents and young university women in Portugal. The distribution of HPV genotypes was evaluated by PCR DNA genotyping after self-sampling collection from 435 women of exfoliated cervical cells using a commercial kit. We observed an overall frequency of HPV infection of 11.5%. Furthermore, HPV DNA prevalence was 16.6% in those young women that self-declared as sexually active. The more frequently detected HPV types were 31, 16, 53, and 61. Statistical analysis identified median age (OR = 3.56; P = 0.001), the number of lifetime sexual partners (OR = 4.50; P < 0.001), and years of sexual activity (OR = 2.36; P = 0.008) as risk factors for HPV acquisition. Hence, our study revealed that oncogenic HPV infection is common in young asymptomatic women Portuguese women, with a history of 25 sexual partners and over 2 year of sexual activity. Moreover, these results demonstrate that HPV detection performed in self-collected samples may be important to appraise better preventive strategies and to monitorize the influence of vaccination programmes within different populations. Copyright © 2011 Jani Silva et al.

Language: English

Type (Professor's evaluation): Scientific