The impact of GGH -401C > T polymorphism on cisplatin-based chemoradiotherapy response and survival in cervical cancer

• Type: Article in International Scientific Journal
• Date: 2013

Authors

Ines Hilario Silva (Author) Other; Cristina Nogueira Silva (Author) Other; Tiago Figueiredo (Author) Other; Liliana Lombo (Author) Other; Ilda Faustino (Author) Other; Raquel Catarino (Author) Other; Augusto Nogueira (Author) Other; Deolinda Pereira (Author) Other; Rui Medeiros (Author) ICBAS

Journal

Title: Gene

Vol. 512

Pages: 247-250

ISSN: 0378-1119

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 7 Citations

Scopus - 7 Citations

Scientific classification

FOS: Natural sciences > Earth and related Environmental sciences

Other information

Authenticus ID: P-002-19J

DOI: 10.1016/j.gene.2012.10.038

Abstract (EN): Aims: Cervical cancer is the third most frequent cancer in women worldwide, mostly treated with cisplatin-based chemoradiotherapy. Since it is known that folate metabolism might interfere with cisplatin effectiveness, we intended to study the influence of the Gamma Glutamyl Hydrolase -401C > T polymorphism in treatment response in cervical cancer. Methods: We retrospectively reviewed the clinical data of 167 patients with bulky cervical cancer submitted to cisplatin-based chemoradiotherapy. The genotypes of GGH -401C > T SNP were determined by real-time PCR and statistical analysis was performed by chi(2) test and survival analysis. Results: The genotypes of GGH-401C > T were significantly associated with the response to platinum-based chemoradiotherapy. Treatment response was higher in patients carrying the CC genotype, who presented a significant increased chance of treatment response (survival time in months/genotype: 91 for CC Vs 72 for CT/TT; p = 0.035, log rank test). A Cox regression analysis accordingly showed that the presence of the T allele was significantly linked to a worse treatment response (HR = 3.036; CI 95% 1.032-8.934, p = 0.044). Conclusions: The results of our study suggested the potential interest of GGH -401C > T as a predictive factor of the outcome of cervical carcinoma treated with cisplatin-based chemoradiotherapy.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 4