Small Molecules in the Cone Snail Arsenal

• Type: Article in International Scientific Journal
• Date: 2015

Authors

Jorge L B Neves (Author) Other; Zhenjian J Lin (Author) Other; Julita S Imperial (Author) Other; Agostinho Antunes (Author) FCUP; Vitor Vasconcelos (Author) FCUP; Baldomero M Olivera (Author) Other; Eric W Schmidt (Author) Other

Journal

Title: Organic Letters

Vol. 17

Pages: 4933-4935

ISSN: 1523-7060

Publisher: American Chemical Society

Indexing

ISI Web of Knowledge - 20 Citations

Scopus - 21 Citations

Scientific classification

FOS: Natural sciences > Chemical sciences

Other information

Authenticus ID: P-00G-SFE

DOI: 10.1021/acs.orglett.5b02389

Abstract (EN): Cone snails are renowned for producing peptide-based venom, containing conopeptides and conotoxins, to capture their prey. A novel small-molecule guanine derivative with unprecedented features, genuanine, was isolated from the venom of two cone snail species. Genuanine causes paralysis in mice, indicating that small molecules and not just polypeptides may contribute to the activity of cone snail venom.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 3