Cytokines involved in resistance to Mycobacterium avium in a mouse model of infection

• Type: Article in International Scientific Journal
• Date: 1997

Authors

Appelberg, R (Author) ICBAS; Castro, AG (Author) Other; Silva, RA (Author) Other; Pedrosa, J (Author) Other

Journal

Title: Medical Principles and Practice

Vol. 6

Pages: 97-102

ISSN: 1011-7571

Publisher: Karger

Indexing

ISI Web of Knowledge - 2 Citations

Scopus - 1 Citation

Scientific classification

FOS: Medical and Health sciences > Clinical medicine

Other information

Authenticus ID: P-007-26V

Abstract (EN): To determine the role played by different cytokines in the induction or expression of protective immunity to Mycobacterium avium we administered neutralizing monoclonal antibodies specific for those cytokines to mice infected with a clinical isolate of M. avium. Our results showed that interleukin (IL)-6 and IL-12 are involved in the induction of T cell-dependent immunity and that such immunity was mediated by interferon-gamma (IFN-gamma) and tumour necrosis factor-alpha (TNF-alpha). Also, induction of innate immunity required IL-12 and was expressed through the secretion of IFN-gamma and TNF-alpha.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 6