Urocortin 2 in cardiovascular health and disease

• Type: Article in International Scientific Journal
• Date: 2015

Authors

Rui Adao (Author) Other; Diana Santos Ribeiro (Author) Other; Miriam T Rademaker (Author) Other; Adelino F Leite Moreira (Author) Other; Carmen Bras Silva (Author) FCNAUP

Journal

Title: Drug Discovery Today

Vol. 20

Pages: 906-914

ISSN: 1359-6446

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 22 Citations

Scopus - 22 Citations

Scientific classification

FOS: Medical and Health sciences > Basic medicine

Other information

Authenticus ID: P-00G-6QG

DOI: 10.1016/j.drudis.2015.02.012

Abstract (EN): Urocortin (Ucn)-2 - corticotropin-releasing hormone receptor 2 signaling has favorable effects in the cardiovascular system, including coronary vasodilatation, with increased coronary blood flow and conductance and augmented cardiac contractility and output, as well as protection against ischemia/reperfusion injury. Indeed, several animal studies have confirmed the salutary therapeutic effects of Ucn-2 in chronic heart failure, with improvements in cardiac performance and animal survival. In addition, recent clinical trials have demonstrated the benefits of Ucn-2 in patients with stable chronic heart failure on optimal medical therapy.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 9