Urinary fibrogenic cytokines ET-1 and TGF-beta 1 are associated with urinary angiotensinogen levels in obese children

• Type: Article in International Scientific Journal
• Date: 2016

Authors

Morato, M (Author) FFUP; Correia Costa, L (Author) Other; Sousa, T (Author) FMUP; Cosme, D (Author) Other; Guimarães, JT (Author) Other; Guerra, A (Author) Other; Schaefer, F (Author) Other; Afonso, AC (Author) Other; Azevedo, A (Author) Other; Albino Teixeira, A (Author) FMUP

Journal

Title: Pediatric Nephrology

Vol. 31

Pages: 455-464

ISSN: 0931-041X

Publisher: Springer Nature

Indexing

ISI Web of Knowledge - 5 Citations

Scopus - 6 Citations

Other information

Authenticus ID: P-00G-SF1

DOI: 10.1007/s00467-015-3232-1

Abstract (EN): Background Fibrogenic cytokines are recognized as putative drivers of disease activity and histopathological deterioration in various kidney diseases. We compared urinary transforming growth factor beta 1 (U-TGF-beta 1) and endothelin 1 (U-ET-1) levels across body mass index classes and assessed their association with the level of urinary angiotensinogen (U-AGT), a biomarker of intrarenal renin-angiotensin-aldosterone system (RAAS). Methods The was a cross-sectional evaluation of 302 children aged 8-9 years. Ambulatory blood pressure (BP), insulin resistance (HOMA-IR), aldosterone level and renal function were evaluated. U-ET-1, U-TGF-beta 1 and U-AGT levels were determined by immunoenzymatic methods. Results Obese children presented with the lowest levels of U-ET-1 and U-TGF-beta 1, but the difference was only significant for U-ET-1. In obese children, the median levels of both U-ET-1 and U-TGF-beta 1 tended to increase across tertiles (T1-T3) of U-AGT (U-ET-1: T1, 19.9 (14.2-26.3); T2, 32.5 (23.3141.6); T3, 24.8 (18.7-51.5) ng/g creatinine, p=0.007; U-TGF-beta 1: T1, 2.2 (1.8-4.0); T2, 4.3 (2.7-11.7); T3, 4.9 (3.810.1) ng/g creatinine, p=0.004]. In multivariate models, in the obese group, U-ET-1 was associated with HOMA-IR and aldosterone and U-AGT levels, and U-TGF-beta 1 was associated with U-AGT levels and 24 h-systolic BP. Conclusions Whereas the initial hypothesis of higher levels of urinary fibrogenic cytokines in obese children was not confirmed in our study, both TGF-beta 1 and U-ET-1 levels were associated with U-AGT level, which likely reflects an early interplay between tissue remodeling and RAAS in obesity-related kidney injury.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 10