Losartan and atenolol on hypertension induced by adenosine receptor blockade

• Type: Article in International Scientific Journal
• Date: 2003

Authors

Morato, M (Author) FFUP; Sousa, T (Author) Other; Guimaraes, S (Author) Other; Moura, D (Author) Other; Albino Teixeira, A (Author) FMUP

Journal

Title: Autonomic and Autacoid Pharmacology

Vol. 23

Pages: 133-140

ISSN: 1474-8665

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge

Scopus - 6 Citations

Other information

Authenticus ID: P-007-BD0

DOI: 10.1046/j.1474-8673.2003.00287.x

Abstract (EN): 1 The prolonged infusion of 1,3-dipropyl-8-sulfophenylxanthine (DPSPX), a non-selective antagonist of adenosine receptors, induces hypertension, an increase in plasma renin activity and morphological cardiovascular changes. 2 The aim of this work was to evaluate the effects of losartan, a selective AT1 receptor antagonist, and atenolol, a ß-adrenoceptor antagonist, on DPSPX-induced hypertension. 3 Male Wistar rats (250-300 g, n = 4-6) were treated for 1 or 4 weeks with: saline i.p.; DPSPX (90 ¿g kg -1 h-1) i.p.; losartan (15 mg kg-1 day -1) p.o.; atenolol (25 mg kg-1 day-1) p.o.; DPSPX (90 ¿g kg-1 h-1) i.p. + losartan (15 mg kg -1 day-1) p.o.; DPSPX (90 ¿g kg-1 h -1) i.p. + atenolol (25 mg kg-1 day-1) p.o. Blood pressure was measured by the 'tail-cuff' method in conscious animals. Fragments of the mesenteric and tail arteries were processed for morphological study and the mean diameter of the vascular smooth muscle cells was determined. 4 DPSPX increased blood pressure. Losartan and atenolol prevented this rise but had no effect on blood pressure of control rats. DPSPX-treated groups showed hypertrophy of the vascular smooth muscle cells and proliferation of subintimal cells. Losartan but not atenolol prevented these changes. Losartan had no effect on the vascular morphology of control rats, while treatment with atenolol for 4 weeks induced hypertrophy of the vascular smooth muscle cells. 5 Both losartan and atenolol counteract the development of DPSPX-induced hypertension but only losartan prevents the alterations in vascular morphology.

Language: English

Type (Professor's evaluation): Scientific