Hypertension due to blockade of adenosine receptors

• Type: Article in International Scientific Journal
• Date: 2003

Authors

Guimaraes, S (Author) Other; Morato, M (Author) FFUP; Sousa, T (Author) Other; Albino Teixeira, A (Author) FMUP

Journal

Title: PHARMACOLOGY & TOXICOLOGY

Vol. 92

Pages: 160-162

ISSN: 0901-9928

Publisher: Blackwell

Indexing

ISI Web of Knowledge - 8 Citations

Scopus - 9 Citations

Scientific classification

FOS: Medical and Health sciences > Basic medicine

Other information

Authenticus ID: P-000-H93

DOI: 10.1034/j.1600-0773.2003.920404.x

Abstract (EN): Chronic treatment of rats with 90 mug/kg/day DPSPX (1,3-dipropyl-8-sulphophenylxanthine) during seven days leads to a hypertensive state which is characterized by marked morphological changes of the blood vessel walls as well as by important functional alterations. While the angiotensin-converting enzyme (ACE) inhibitor captopril and the antagonist of angiotensin II AT(1) receptors losartan prevent the development of both hypertension and morphological changes, the selective beta(1)-adrenoceptor antagonist atenolol could prevent only the increase in blood pressure. It is concluded that at least two factors are involved in the development of the hypertensive state.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 3