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In vitro mineralisation of human bone marrow cells cultured on Bonelike (R)

Title
In vitro mineralisation of human bone marrow cells cultured on Bonelike (R)
Type
Article in International Scientific Journal
Year
2004
Authors
Maria Adelina Costa
(Author)
ICBAS
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Manuel Gutierres
(Author)
FMUP
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L. Almeida
(Author)
Other
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Maria Ascensão Lopes
(Author)
FEUP
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José Domingos Santos
(Author)
FEUP
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Maria Helena Fernandes
(Author)
FMDUP
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Journal
The Journal is awaiting validation by the Administrative Services.
Vol. 254-2
Pages: 821-824
Scientific classification
FOS: Engineering and technology > Environmental biotechnology
Other information
Authenticus ID: P-000-CBM
Abstract (EN): Bonelike(R) is a CaO-P2O5 based glass-reinforced hydroxyapatite (HA) designed to mimic the inorganic composition of the bone tissue. This work evaluates the response of human bone marrow cells to Bonelike(R) concerning cell proliferation and osteoblast differentiation. HA was used as control material. Results showed that Bonelike(R) allowed the proliferation of bone marrow cells and their complete differentiation, as evidenced by the formation of cell-mediated mineralisation. In comparison with HA, Bonelike(R) had a positive effect on the expression of alkaline phosphatase and also on the formation of a mineralised matrix, two osteoblast markers.
Language: English
Type (Professor's evaluation): Scientific
No. of pages: 4
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