Abstract (EN):
Bonelike(R) is a CaO-P2O5 based glass-reinforced hydroxyapatite (HA) designed to mimic the inorganic composition of the bone tissue. This work evaluates the response of human bone marrow cells to Bonelike(R) concerning cell proliferation and osteoblast differentiation. HA was used as control material. Results showed that Bonelike(R) allowed the proliferation of bone marrow cells and their complete differentiation, as evidenced by the formation of cell-mediated mineralisation. In comparison with HA, Bonelike(R) had a positive effect on the expression of alkaline phosphatase and also on the formation of a mineralised matrix, two osteoblast markers.
Language:
English
Type (Professor's evaluation):
Scientific
No. of pages:
4