Modified model of sub-critical size cranial defect in the rabbit [Modelo modificado de defecto craneal de tamaño subcrítico de conejo]

• Type: Article in International Scientific Journal
• Date: 2010

Authors

Marques, JM (Author) Other; Viegas, C (Author) Other; Dias, MI (Author) Other; Zagalo, C (Author) Other; Gomes, P (Author) FMDUP; Fernandes, MH (Author) FMDUP; Santos, JD (Author) FEUP; Cabrita, SC (Author) Other

Journal

Title: International Journal of Morphology

Vol. 28 No. 2

Pages: 525-528

ISSN: 0717-9367

Publisher: Sociedad Chilena de Anatomia

Indexing

ISI Web of Knowledge

Scopus - 1 Citation

Other information

Authenticus ID: P-007-VH1

Abstract (EN): In medical sciences, any experimental animal model should be reproducible and adequate to the purpose of simulated human physiological response. In bone injury response research, when bone substitutes are in use, it is of primary importance that studied defects fail to heal unless treated with the tissue engineering therapy under study. This failure defines the concept of "critical size defect" (CSD) wich has different limits according to the animal species used and the location of the defect. Although this is a basic concept, when the aim of the study is to investigate the interface Bone-Biomaterial, it is of primary importance to obtain as much contact area as possible. In order to do so, we propose a modified surgical approach to the classical bi-parietal round sub-critical defect model in rabbit vault.

Language: Spanish

Type (Professor's evaluation): Scientific