Continuous-Flow Precipitation of Hydroxyapatite at 37 degrees C in a Meso Oscillatory Flow Reactor

• Type: Article in International Scientific Journal
• Date: 2013

Authors

Filipa Castro (Author) FEUP; António Ferreira (Author) FEUP; Fernando Rocha (Author) FEUP; António Vicente (Author) FEUP; José António Teixeira (Author) FEUP

Journal

Title: Industrial & Engineering Chemistry Research

Vol. 52 No. 29

Pages: 9816-9821

ISSN: 0888-5885

Publisher: American Chemical Society

Indexing

ISI Web of Knowledge - 27 Citations

Scopus - 27 Citations

Scientific classification

FOS: Engineering and technology > Chemical engineering

Associated Projects

UI0511 - PROJECTO ESTRATÉGICO - UI 511 - 2013-2014

Other information

Authenticus ID: P-006-93R

DOI: 10.1021/ie400710b

Abstract (EN): Continuous-flow precipitation of hydroxyapatite (HAp) was investigated in a meso oscillatory flow reactor (meso-OFR) and in a scaled-up meso-OFR, obtained by associating in series eight vertical meso-ORFs. Experiments were carried out under near-physiological conditions of temperature and pH, using fixed frequency (f = 0.83 Hz) and amplitude (x(0) = 4.5 mm), and varying the residence time from 0.4 to 6.7 min. It has been shown that the mean particle size and the aggregation degree of the prepared HAp particles decrease with decreasing residence time. HAp nanoparticles with a mean size (d(50)) of 77 nm, narrow size distribution, and uniform morphology were obtained at the lowest residence times, tau = 0.4 and 3.3 min in the meso-OFR and the scaled-up meso-OFR, respectively. These results show the capability of the meso-OFR and the scaled-up meso-OFR for continuous production of uniform HAp nanoparticles, while also confirming the possibility of OFR scale-up by in series association of individual OFRs.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 6