Encapsulation of a proteasome inhibitor with gold-polysaccharide nanocarriers

• Type: Article in International Scientific Journal
• Date: 2014

Authors

Sandra Rocha (Author) FEUP; Paula Sampaio (Author) Other; Maria Carmo Pereira (Author) FEUP; Manuel A. N. Coelho (Author) FEUP; Sílvia Castro Coelho (Author) FEUP

Journal

Title: Journal of Nanoparticle Research

Vol. 16 No. 4

ISSN: 1388-0764

Publisher: Springer Nature

Indexing

ISI Web of Knowledge - 3 Citations

ISI Web of Science

Scopus - 3 Citations

INSPEC

Scientific classification

FOS: Engineering and technology

CORDIS: Health sciences ; Technological sciences

Associated Projects

BIONANO - Distibuição de biomoleculas através de nanopartículas inorganica/organicas

Other information

Authenticus ID: P-009-CHP

DOI: 10.1007/s11051-014-2368-4

Abstract (EN): Organic-inorganic hybrid nanoparticles are potential effective systems for drug delivery in cancer therapy and diagnosis. Chitosan-gum arabic with entrapped gold nanoparticles were developed as a carrier for an anticancer drug bortezomib. The nanosystem was designed to enhance the proteasome inhibitor activity in pancreatic cell lines, S2-013 and hTERT-HPNE. The hydrodynamic diameter of chitosan-gum arabic-gold nanoparticles loaded with bortezomib is around 330 nm. Laser scanning confocal microscopy images show the uptake of the gold nanoparticle/bortezomib encapsulated in chitosan-gum arabic matrix and the fast internalization of these nano combinations into pancreatic cells. Cytotoxic assays assessed that positively charged nanosystems reduce the cell growth and cell proliferation of S2-013s, but the same effect was not observed in cytotoxic response in hTERT-HPNE cells. The outcomes of this study demonstrate the capacity of chitosan-gum arabic nanocarriers to deliver gold nanoparticles/anticancer drug and to increase the permeation and retention effect in S2-013 cells and minimize drug side effects in HPNE cells. © 2014 Springer Science+Business Media.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 10