Prevalence and spread of extended-spectrum beta-lactamase-producing Enterobacteriaceae in Europe

• Type: Article in International Scientific Journal
• Date: 2008

Authors

Canton, R (Author) Other; Novais, A (Author) Other; Valverde, A (Author) Other; Machado, E (Author) Other; Peixe, L (Author) FFUP; Baquero, F (Author) Other; Coque, TM (Author) Other

Journal

Title: Clinical Microbiology and Infection

Vol. 14 No. 1

Pages: 144-153

ISSN: 1198-743X

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 362 Citations

Scopus - 463 Citations

Scientific classification

FOS: Medical and Health sciences > Health sciences

Other information

Authenticus ID: P-004-2TR

DOI: 10.1111/j.1469-0691.2007.01850.x

Abstract (EN): Extended-spectrum beta-lactamases (ESBLs) represent a major threat among resistant bacterial isolates. The first types described were derivatives of the TEM-1, TEM-2 and SHV-1 enzymes during the 1980s in Europe, mainly in Klebsiella pneumoniae associated with nosocomial outbreaks. Nowadays, they are mostly found among Escherichia coli isolates in community-acquired infections, with an increasing occurrence of CTX-M enzymes. The prevalence of ESBLs in Europe is higher than in the USA but lower than in Asia and South America. However, important differences among European countries have been observed. Spread of mobile genetic elements, mainly epidemic plasmids, and the dispersion of specific clones have been responsible for the increase in ESBL-producing isolates, such as those with TEM-4, TEM-24, TEM-52, SHV-12, CTX-M-9, CTX-M-14, CTX-M-3, CTX-M-15 and CTX-M-32 enzymes.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 10