Public Health Risks of Enterobacterial Isolates Producing Extended-Spectrum beta-Lactamases or AmpC beta-Lactamases in Food and Food-Producing Animals: An EU Perspective of Epidemiology, Analytical Methods, Risk Factors, and Control Options

• Type: Article in International Scientific Journal
• Date: 2013

Authors

Ernesto Liebana (Author) Other; Alessandra Carattoli (Author) Other; Teresa M Coque (Author) Other; Henrik Hasman (Author) Other; Anna Pelagia Magiorakos (Author) Other; Dik Mevius (Author) Other; Luisa Peixe (Author) FFUP; Laurent Poirel (Author) Other; Gertraud Schuepbach Regula (Author) Other; Karolina Torneke (Author) Other; Jordi Torren Edo (Author) Other; Carmen Torres (Author) Other; John Threlfall (Author) Other

Journal

Title: Clinical Infectious Diseases

Vol. 56

Pages: 1030-1037

ISSN: 1058-4838

Publisher: Oxford University Press

Indexing

ISI Web of Knowledge - 127 Citations

Scopus - 182 Citations

Scientific classification

FOS: Medical and Health sciences > Basic medicine

Other information

Authenticus ID: P-005-2AE

DOI: 10.1093/cid/cis1043

Abstract (EN): The bla(ESBL) and bla(AmpC) genes in Enterobacteriaceae are spread by plasmid-mediated integrons, insertion sequences, and transposons, some of which are homologous in bacteria from food animals, foods, and humans. These genes have been frequently identified in Escherichia coli and Salmonella from food animals, the most common being bla(CTX-M-1), bla(CTX-M-14), and bla(CMY-2). Identification of risk factors for their occurrence in food animals is complex. In addition to generic antimicrobial use, cephalosporin usage is an important risk factor for selection and spread of these genes. Extensive international trade of animals is a further risk factor. There are no data on the effectiveness of individual control options in reducing public health risks. A highly effective option would be to stop or restrict cephalosporin usage in food animals. Decreasing total antimicrobial use is also of high priority. Implementation of measures to limit strain dissemination (increasing farm biosecurity, controls in animal trade, and other general postharvest controls) are also important.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 8