Autosomal recessive limb-girdle muscular dystrophies diagnosed at Coimbra university hospital [Distrofias musculares das cinturas autossómicas recessivas diagnosticadas nos hospitais da universidade de Coimbra]

• Type: Article in International Scientific Journal
• Date: 2012

Authors

Negrao, L (Author) Other; Geraldo, A (Author) Other; Rebelo, O (Author) Other; Matos, A (Author) Other; Santos, R (Author) Other; Bronze da Rocha, E (Author) FFUP

Journal

Title: Sinapse

Vol. 12

Pages: 13-21

ISSN: 1645-281X

Publisher: Sociedade Portuguesa de Neurologia

Indexing

ISI Web of Knowledge

Scopus - 2 Citations

Other information

Authenticus ID: P-008-4X8

Abstract (EN): Introduction Limb-girdle muscular dystrophies (LGMDs) are a heterogeneous group of muscle diseases. Autosomal dominant (LGMD1) and recessive (LGMD2) forms are recognized, each one with several subtypes. In Portugal there are no studies reporting the relative distribution of the different subtypes of LGMD2. Objective To determine the subtypes of LGMD2 diagnosed and their relative distribution at the Neurology Department of the Coimbra University Hospital. Material and Methods The medical files of the patients with a diagnosis of LGMD2 were analysed and individual clinical, laboratory, pathologic and molecular data were recorded. The time frame of analysis was from 2000 to 2010. Results Forty-two patients from thirty-nine unrelated families were identified with a LGMD2 diagnosis. There were twentythree female and nineteen male patients. Parental consanguinity was reported in eighteen patients (fifteen families). Their actual mean age is 44.6 years and the mean age of first symptoms was 23.2 years. The mean time from first symptoms to genetic diagnosis was 16.2 years. Twenty patients are wheelchair bound and seventeen can't raise the arms above the shoulder level. Three patients presented symptomatic dilated cardiomyopathy and twelve patients a restrictive respiratory syndrome, which was severe in five. The mean CK value was elevated in all LGMD2 subtypes. Immunohistochemistry suggested the specific diagnosis in twenty patients (LGMD2B: 11; LGMD2C-F: 9). Molecular studies performed in forty-one patients revealed 27 homozygous mutations, 11 compound heterozygous mutations and 3 heterozygous mutations. The LGMD2 subtypes diagnosed and the number of patients of each subtype was: LGMD2A: 5, LGMD2B: 16, LGMD2C-F: 9 (one patient without molecular study), LGMD2G: 1, LGMD2I: 7, LGMD2J: 1, LGMD2L: 3. Conclusion This retrospective analysis shows that most of the autosomal recessive LGMDs subtypes are represented in Portugal, being the LGMD2B subtype the most frequent. Rarer subtypes, like LGMD2G and J, were also found rare.

Language: English

Type (Professor's evaluation): Scientific